Protein sorting in the Golgi complex
نویسندگان
چکیده
منابع مشابه
Sorting and Signaling at the Golgi Complex
branes, while GTP hydrolysis is thought to trigger membrane release of COPI into the cytosol, making COPI available for repeated cycles of coat assembly and dis-assembly. ARF1 thus operates as a binary switch to The Golgi complex functions at the crossroads of the control COPI assembly onto membranes and thereby secretory pathway, receiving newly synthesized pro-to regulate its function. teins ...
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Protein traffic is of critical importance for normal cellular physiology. In eukaryotes, spherical transport vesicles move proteins and lipids from one internal membrane-bound compartment to another within the secretory pathway. The process of directing each individual protein to a specific destination (known as protein sorting) is a crucial event that is intrinsically linked to vesicle biogene...
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To explain how resident proteins distribute in peak-like patterns at various positions in the secretory pathway, Glick and co-workers postulated that resident proteins comprise different populations (termed kin populations) and that these compete with each other for entering retrograde transport carriers [Glick et al. (1997) FEBS Lett. 414, 177-181]. Using modelling and computer simulation, the...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 1998
ISSN: 0167-4889
DOI: 10.1016/s0167-4889(98)00048-2